产品货号：
Z11177
中文名称：
ASPP1/PPP1R13B抗体
英文名称：
Anti-ASPP1/PPP1R13B Antibody
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ASPP1/PPP1R13B Antibody |
| 指标别名 | ASPP1;ASPP-1;ASPP 1;p53BP2 like;p85;PPP1R13B |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | ELISA,WB |
| 基因名称 | PPP1R13B |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal sequence of human ASPP1. |
| 计算分子量 | 119kDa |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | This affinity purified antibody is directed against human ASPP1.The product was affinity purified from monospecific antiserum by immunoaffinity chromatography.Minimal reactivity occurs against ASPP2.A BLAST analysis was used to suggest cross-reactivity with ASPP1 from mouse based on a 92% homology with the immunizing sequence.Reactivity against homologues from other sources is not known. |
| 浓度 | 0.33mg/mL by UV absorbance at 280nm |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | ASPP (ankyrin-repeat-,SH3-domain- proline-rich-region protein) proteins (ASPP1,ASPP2 and iASPP) represent a new family of p53 binding proteins.ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis.In contrast,iASPP functionally inactivates p53.ASPPs may also regulate p63- and p73-mediated apoptosis.Both ASPP1 and 2 directly interact with p53 and specifically enhance the apoptotic function of p53 by stimulating its DNA binding and transactivation function on promoters of pro-apoptotic genes,such as Bax and PIG-3.Not all cell cycle arrest genes are affected,such as p21.?Interestingly,expression of ASPP is frequently down-regulated in human breast carcinomas expressing wild-type p53 but not mutant p53.Therefore,ASPP might regulate the tumor suppression function of p53 in vivo. |
| Uniprot ID | Q96KQ4 |
| 基因名全称 | Apoptosis-stimulating of p53 protein 1 |
| 推荐稀释比 | ELISA:1:2,500 - 1:10,000 WB:1:500 - 1:3,000 |
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